Unlocking Longevity: The Science of Supplements

🔬NAD boosters, such as NMN and NR, can enhance longevity by activating the sirtuins pathway and boosting cellular energy production.

💊Metformin, a widely-used diabetes drug, has potential anti-aging effects by activating AMPK and reducing inflammation.

🌿Berberine, a natural compound found in plants, can mimic the effects of Metformin and enhance glucose metabolism.

🌰Rapamycin, a prescription drug used in organ transplants, can extend lifespan by inhibiting the mTOR pathway and slowing down cellular aging.

🌻Spermidine, found in foods like wheat germ and soybeans, can prevent age-related decline and promote autophagy.

Are these supplements safe?

—While many of these supplements and drugs are generally recognized as safe, long-term use should be monitored by a healthcare professional. Some may have side effects or interact with other medications.

Do I need to take all of these supplements?

—No, it's important to prioritize your individual needs and goals. Consulting with a healthcare professional can help determine which supplements are most suitable for you.

Can supplements replace a healthy lifestyle?

—Supplements should complement a healthy lifestyle, including proper nutrition, exercise, and sleep. They are not a substitute for overall well-being.

How do these supplements work together?

—These supplements can interact with multiple longevity pathways and have varying effects. Understanding their mechanisms of action and potential synergies is an area of ongoing research.

Where can I find more information about these supplements?

—Scientific references and additional resources can be found in the show notes and on reliable sources, such as PubMed and reputable medical websites.

00:10Introduction to the sirtuins, AMPK, and mTOR pathways and their roles in longevity.

00:22Overview of NAD boosters, including NMN and NR, and their ability to activate the sirtuins pathway and enhance cellular energy production.

02:47Exploration of Metformin, a widely-used diabetes drug, and its potential anti-aging effects through AMPK activation and inflammation reduction.

04:56Discussion of berberine, a natural compound, and its ability to mimic the effects of Metformin in enhancing glucose metabolism.

07:01Explanation of rapamycin, a prescription drug used in organ transplants, and its role in extending lifespan by inhibiting the mTOR pathway and slowing down cellular aging.

09:08Introduction to spermidine, a compound found in foods like wheat germ and soybeans, and its potential in preventing age-related decline and promoting autophagy.