Understanding Therapeutic Drug Monitoring for Inflammatory Bowel Disease

🔬TDM involves measuring the concentration of biologic drugs in a patient's blood and adjusting the dosage accordingly.

💉Optimizing the drug concentration helps minimize side effects and reduce the risk of developing antibodies.

🔄TDM is crucial for maintaining remission and preventing the loss of response to the medication over time.

💲By optimizing the treatment, TDM helps reduce the costs associated with managing inflammatory bowel disease.

🌱TDM improves the overall health and well-being of patients with inflammatory bowel disease.

What is therapeutic drug monitoring (TDM)?

—TDM involves measuring the concentration of biologic drugs in a patient's blood and adjusting the dosage based on the results.

Why is TDM important in the treatment of inflammatory bowel disease?

—TDM helps optimize the effectiveness of the medication, minimize side effects, and reduce the risk of developing antibodies.

When should the drug concentration be measured?

—The drug concentration should be measured just before the next dose is administered, known as the trough level.

What are the risks of having a drug concentration that is too high?

—Having a drug concentration that is too high increases the risk of side effects.

What are the risks of having a drug concentration that is too low?

—Having a drug concentration that is too low increases the risk of developing antibodies, which can lead to a loss of response over time.

00:00This video provides an overview of therapeutic drug monitoring (TDM) for inflammatory bowel disease (IBD).

00:26In IBD, the inflammation is caused by an excessive production of TNF-alpha.

01:27TDM involves measuring the drug concentration in the patient's blood.

01:48The drug concentration should be measured just before the next dose is administered.

02:03Optimizing the drug concentration helps minimize side effects and reduce the risk of developing antibodies.

02:14TDM is crucial for maintaining remission and preventing the loss of response to the medication over time.

02:17TDM improves the overall health and well-being of patients with IBD.

02:33Therapeutic drug monitoring of infliximab and adalimumab has been shown to be effective in IBD.