Understanding Pharmacokinetics: How Your Body Interacts with Medication

🔍Pharmacokinetics is the study of how medications move and interact in the body.

⏰The process of pharmacokinetics can be divided into four components: absorption, distribution, metabolism, and elimination.

💊Medications are administered through different routes, such as oral, intravenous, inhalation, and transdermal.

🩸Absorption involves the movement of medications from the site of administration into the bloodstream. It can occur through passive diffusion, facilitated diffusion, active transport, or endocytosis.

🧬Distribution refers to the movement of medications from the bloodstream into the body's tissues. Factors influencing distribution include blood supply, lipid solubility, and plasma protein binding.

What is bioavailability?

—Bioavailability is the fraction of an administered medication that eventually reaches the circulation in its unchanged form.

What is the first pass effect?

—The first pass effect is the metabolism of a medication in the liver before it enters the general circulation.

How does the pH of the environment affect absorption?

—The pH of the environment can influence the ratio between the charged and uncharged forms of a medication, affecting its absorption.

What is the blood-brain barrier?

—The blood-brain barrier is a selectively permeable membrane that regulates the passage of medications into the brain.

How does protein binding affect distribution?

—Medications that are bound to plasma proteins have a limited ability to diffuse into tissues, as only the unbound fraction is free to do so.

00:03Pharmacokinetics refers to the movement and modification of medication in the body.

03:32Absorption is the process of moving medication from the site of administration into the bloodstream.

11:41Distribution involves the movement of medication from the bloodstream into the body's tissues.

13:10Metabolism refers to the breakdown and modification of medication in the liver.

13:25Elimination is the process of excreting medication through urine or feces.

14:19Bioavailability is the fraction of an administered medication that reaches the circulation unchanged.

16:00The first pass effect refers to the metabolism of medication in the liver before it enters the general circulation.

19:29The pH of the environment can affect the absorption of medication, as it can influence the ratio between charged and uncharged forms.