🔬Cancer drugs work by targeting specific phases of the cell cycle.
💊Mitosis inhibitors, such as vincristine and vinblastine, prevent cell division by inhibiting microtubule formation.
🔗G1 phase inhibitors, such as cisplatin and cyclophosphamide, cross-link DNA to prevent cell growth.
🧪Pulmonary fibrosis is a side effect of busulfan, a G1 phase inhibitor.
⚠️Cyclophosphamide can cause hemorrhagic cystitis, a potentially serious adverse reaction.
What is the purpose of cancer drugs?
—Cancer drugs help inhibit the growth of cancer cells and prevent their spread throughout the body.
How do mitosis inhibitors work?
—Mitosis inhibitors, such as vincristine and vinblastine, disrupt the formation of the mitotic spindle, preventing cell division.
What are the side effects of G1 phase inhibitors?
—G1 phase inhibitors, like cisplatin and cyclophosphamide, can cause nephrotoxicity and hemorrhagic cystitis, respectively.
What is the mechanism of action of busulfan?
—Busulfan, a G1 phase inhibitor, cross-links DNA to inhibit cell growth. It can also cause pulmonary fibrosis as a side effect.
Why is cyclophosphamide associated with a high risk of adverse reactions?
—Cyclophosphamide has the potential to cause serious adverse reactions, such as hemorrhagic cystitis, and requires hospital monitoring.
00:00This video provides a simplified overview of cancer drugs, focusing on their impact on the cell cycle.
01:36Mitosis inhibitors, like vincristine and vinblastine, prevent cell division by inhibiting microtubule formation.
08:20G1 phase inhibitors, such as cisplatin and cyclophosphamide, cross-link DNA to inhibit cell growth.
09:39Busulfan, a G1 phase inhibitor, can cause pulmonary fibrosis as a side effect.
09:43Cyclophosphamide can cause hemorrhagic cystitis, a potentially serious adverse reaction.
