Tom Brady's draft to the Patriots in the sixth round proved to be one of the greatest steals in NFL history.
Jamal Lewis's dominant 2003 season established him as one of the best running backs in the league.
Shawn Alexander's record-breaking 2005 season earned him both the MVP and Offensive Player of the Year awards.
Thomas Jones struggled in his early years with the Cardinals but found success with the Bears and Jets.
Despite injuries and concussions, these running backs have left a lasting legacy in the NFL.