🔬The manufacturing process for the Pfizer COVID-19 vaccine involved two different methods.
🧬Process 1 used PCR to duplicate DNA, while Process 2 involved using E. coli bacteria and plasmid DNA.
⚠️Process 2 resulted in the presence of DNA remnants and endotoxins.
💡The Cutter incident in the 1950s highlighted the importance of the manufacturing process in vaccine safety.
❓Only 252 people were tested with Process 2, raising concerns about the change in product and the need for further analysis.
What is the Cutter incident?
—The Cutter incident refers to a vaccine manufacturing error in the 1950s where a polio vaccine caused cases of polio due to live virus contamination.
Why did Pfizer use two different manufacturing processes?
—Pfizer used Process 1 in the clinical trial and Process 2 for public use due to scalability and cost-effectiveness.
What are DNA remnants and endotoxins?
—DNA remnants are leftover genetic material, while endotoxins are inflammatory substances found in gram-negative bacteria such as E. coli.
What lessons can we learn from the Cutter incident?
—The Cutter incident serves as a reminder of the importance of a precise and controlled manufacturing process in ensuring vaccine safety.
Why were only 252 people tested with Process 2?
—The clinical trial initially planned to compare Process 1 and Process 2, but only 252 people were tested with Process 2, raising concerns about the lack of sufficient data.
00:00The Pfizer COVID-19 vaccine went through two different manufacturing processes.
06:41The Cutter incident in the 1950s highlighted the importance of the manufacturing process in vaccine safety.
10:36Only 252 people were tested with the Process 2 vaccine, raising concerns about the change in product and the need for further analysis.
