⚙️Regulation occurs at DNA, transcription, and translational levels.
🧬Epigenetic modifications play a crucial role in DNA availability for transcription.
🔬Histone acetylation and methylation impact gene expression by altering DNA-histone interaction.
🕰️Post-transcriptional modifications like splicing and editing influence mRNA stability and protein synthesis.
🔗Transcriptional factors and DNA binding motifs regulate the transcription process.
What are the key levels at which gene expression is regulated in eukaryotes?
—Gene expression in eukaryotes is regulated at DNA, transcriptional, translational, post-transcriptional, and post-translational levels.
How do epigenetic modifications impact gene regulation?
—Epigenetic modifications, such as acetylation and methylation, alter histone-DNA interactions to control DNA accessibility for transcription.
What role do histone modifications play in gene expression?
—Histone modifications, like acetylation, influence gene expression by modulating DNA-histone interactions, impacting DNA accessibility for transcription.
What are post-translational modifications and how do they affect gene expression?
—Post-translational modifications like splicing and editing in mRNA influence mRNA stability and protein synthesis, crucial for regulating gene expression.
How do transcriptional factors contribute to gene regulation?
—Transcriptional factors, along with DNA binding motifs, play a significant role in regulating gene expression by controlling the transcription process.
00:04Introduction to the regulation of gene expression in eukaryotes.
01:10Discussion on regulation occurring at different levels: DNA, transcription, and translation.
05:32Explanation of epigenetic modifications impacting DNA availability for transcription.
09:24Insight into post-transcriptional modifications like splicing and editing.
12:25Role of histone acetylation and methylation in gene regulation.
16:41Overview of histone acetylation and its impact on DNA availability.
